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KMID : 0614019880040010069
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Journal of Pharmaceutical Sciences (C.N.U.)
1988 Volume.4 No. 1 p.69 ~ p.76
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Changes in Emotional Behavior Induced by Brain Lesion
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Lee Soon-Chul
T. Yamamoto
S. Ueki
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Abstract
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Nucleus accumbens septi (NAB), one of mesolimbic system, which anatomically related the limbic system. We an attempted to elucidated emotional changes following bilateral NAB lesions in rats. Caudal, rostral and both areas of NAB were lesioned each in separated animal groups. Furthermore, aggressive behavior induced by NAB rats was investigated in comparison with those induced by olfactory bulbectomized rats and raphe nucleus-lesioned rats.
1) At postoperative day 2, locomotor activity were increased in r-NAB rats but not in c-NAB rats.
2) All rats exhibited hyperirritability and muricide including mouse-eating behavior after NAB lesions.
3) Muricide of NAB rats was significantly supressed by L-DOPA, L-5-HTP and antidepressants, muricide of raphe rats was also significantly inhibited by L-DOPA and L-5-HTP, while that in OB rats was not suppressed.
These results suggested that the NAB plays an important role in locomotor activity and aggression. The characteristics of aggressive behavior induced by NAB rats resemble to that of raphe-rats.
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